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Cannabis and Cannabinoid Research

The only peer-reviewed journal dedicated to the scientific, medical, and psychosocial exploration of clinical cannabis, cannabinoids, and and the endocannabinoid system.

This journal is an amazing resource for anyone who is interested in reading primary research literature and peer-reviewed perspective pieces. Many of its articles are open access!


Dustin Sulak, D.O. is a renowned integrative medicine physician based in Maine, whose practice balances the principles of osteopathy, mind-body medicine and medical cannabis. Regarded as an expert on medical cannabis nationally, Dr. Sulak educates medical providers and patients on its clinical use, while continuing to explore the therapeutic potential of this ancient yet emerging medicine.

Dr. Sulak received undergraduate degrees in nutrition science and biology from Indiana University, a doctorate of osteopathy from the Arizona College of Osteopathic Medicine, and completed an internship at Maine-Dartmouth Family Medicine Residency.




National Academies of Sciences, Engineering, and Medicine; Health and Medicine DivisionBoard on Population Health and Public Health PracticeCommittee on the Health Effects of Marijuana: An Evidence Review and Research Agenda


Significant changes have taken place in the policy landscape surrounding cannabis legalization, production, and use. During the past 20 years, 25 states and the District of Columbia have legalized cannabis and/or cannabidiol (a component of cannabis) for medical conditions or retail sales at the state level and 4 states have legalized both the medical and recreational use of cannabis. These landmark changes in policy have impacted cannabis use patterns and perceived levels of risk.

However, despite this changing landscape, evidence regarding the short- and long-term health effects of cannabis use remains elusive. While a myriad of studies have examined cannabis use in all its various forms, often these research conclusions are not appropriately synthesized, translated for, or communicated to policy makers, health care providers, state health officials, or other stakeholders who have been charged with influencing and enacting policies, procedures, and laws related to cannabis use. Unlike other controlled substances such as alcohol or tobacco, no accepted standards for safe use or appropriate dose are available to help guide individuals as they make choices regarding the issues of if, when, where, and how to use cannabis safely and, in regard to therapeutic uses, effectively.

Shifting public sentiment, conflicting and impeded scientific research, and legislative battles have fueled the debate about what, if any, harms or benefits can be attributed to the use of cannabis or its derivatives, and this lack of aggregated knowledge has broad public health implications. The Health Effects of Cannabis and Cannabinoids provides a comprehensive review of scientific evidence related to the health effects and potential therapeutic benefits of cannabis. This report provides a research agenda—outlining gaps in current knowledge and opportunities for providing additional insight into these issues—that summarizes and prioritizes pressing research needs.

Can be found here: https://www.nap.edu/catalog/24625/the-health-effects-of-cannabis-and-cannabinoids-the-current-state


1. The Health Effects of Cannabis and Cannabinoids

National Academies of Sciences, Engineering, and Medicine. 2017. The Health Effects of Cannabis and Cannabinoids: The Current State of Evience and Recommendations for Research. Washington, DC: The National Academices Press.

2. Medical Cannabis Laws and Opioid Analgesic Overdose Mortality in the United States, 1999-2010

Bachhuber, M.A., Saloner, B., Cunningham, C. O., and Barry, C. L. 2014. Medical Cannabis Laws and Opioid Analgesic Overdose Mortality in the United States, 1999-2010. JAMA Internal Medicine, 174(10), 1668-1673.

3. Multiple Functions of Endocannabinoid Signalling in the Brain

Katona, I., and Freund, T. F. 2012. Multiple Functions of Endocannabinoid Signaling in the Brain. Annual Review of Neuroscience, 35, 529-558.

4. The Endocannabinoid System: a System General View and Latest Additions.

Petrocellis, L. D., Cascio, M. G., and Marzo, V. D. 2004. The Endocannabinoid System: a General View and Latest Additions. British Journal of Pharmacology, 141(5), 765-774.

5. A Potted History

Pain, S. 2015. A Potted History, Nature 525, S10-S11.

6. Plant-Based Cannabinoids for the Treatment of Chronic Neuropathic Pain

Casey, S. L., and Vaughan, C. W. 2018. Plant-Based Cannabinoids for the Treatment of Chronic Neuropathic Pain. Medicines, 5(3), 67.

7. Evidence for the use of “Medical Marijuana” in Psychiatric and Neurologic Disorders

Noel, C. 2017. Evidence for the use of “medical marijuana” in psychiatric and neurologic disorders. The Mental Health Clinician, 7(1), 29-38.

8. Does Cannabis Cause, Exacerbate, or Ameliorate Psychiatric Disorders? An Oversimplified Debate Discussed

Haney, M., and Evins, A. E. 2016. Does Cannabis Cause, Exacerbate, or Ameliorate Psychiatric Disorders? An Oversimplified Debate Discussed. Neuropsychopharmacology, 41(2), 393-401.

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